Overview
Targeted therapy uses drugs designed to attack specific molecules or pathways that cancer cells depend on for growth and survival. While no targeted therapies are currently FDA-approved specifically for mesothelioma, several are being studied in clinical trials, particularly those targeting the Hippo pathway and BAP1 mutations.
Who May Be a Candidate
- Patients with specific genetic mutations
- Those who have progressed on standard treatment
- Clinical trial participants
- Tumors with identified drug targets
How It Works
Targeted drugs interfere with specific molecules that cancer cells need to grow and spread. Unlike chemotherapy, which kills rapidly dividing cells generally, targeted therapy aims to affect cancer cells while sparing normal cells.
Procedure Steps
- Tumor genetic testing to identify targets
- Evaluation for clinical trial eligibility
- Treatment administered (usually oral pills)
- Regular monitoring for response and side effects
- Imaging to assess tumor response
Benefits
- May work when chemotherapy has failed
- Generally fewer side effects than chemotherapy
- Can be taken at home (oral medications)
- Precision approach targets cancer-specific changes
Risks & Side Effects
- Side effects vary by specific drug
- Resistance may develop over time
- Limited availability (mostly clinical trials)
- Not all tumors have targetable mutations
Recovery
Ongoing treatment without traditional recovery period. Side effects managed throughout treatment. Regular monitoring required.
Expected Outcomes
Clinical trials of targeted therapies like VT3989 (TEAD inhibitor) have shown promising results, with some patients achieving disease control for extended periods. Research continues to identify additional targets.
Finding Treatment
This procedure is typically performed at specialized mesothelioma treatment centers with experienced surgical teams. Consulting with a mesothelioma specialist is the first step in determining if this treatment is appropriate for your situation.