Featured Trials

These Phase 2 and Phase 3 trials represent the most promising treatments currently being studied for mesothelioma.

PHASE2 NCT05930665

Study of Cadonilimab Combined With Bevacizumab and Standard Chemotherapy as First Line Therapy in Unresectable Pleural Mesothelioma

Enrolling: 38
View on ClinicalTrials.gov →
PHASE2 NCT06318286

Study of Pembrolizumab Plus Chemotherapy With Lenvatinib for Malignant Pleural Mesothelioma

Enrolling: 25
View on ClinicalTrials.gov →
PHASE2 NCT06543069

Sintilimab, Bevacizumab, Pemetrexed, and Cisplatin for Unresectable MPeM

Enrolling: 28
View on ClinicalTrials.gov →
PHASE1/PHASE2 NCT06051695

A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression

Enrolling: 474
View on ClinicalTrials.gov →
PHASE2 NCT06477419

A Study of Sacituzumab Govitecan in People With Mesothelioma

Enrolling: 33
View on ClinicalTrials.gov →
PHASE1/PHASE2 NCT03556228

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

Enrolling: 242
View on ClinicalTrials.gov →
PHASE2 NCT06503146

18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection

Enrolling: 320
View on ClinicalTrials.gov →

Understanding Clinical Trials

Clinical trials test new treatments before they become widely available. For mesothelioma patients, trials often provide access to cutting-edge therapies that may be more effective than standard treatments.

Trial Phases Explained

Phase 1

Tests safety and dosing in a small group (15-30 patients). Focuses on finding the right dose with acceptable side effects.

21 trials

Phase 2

Tests effectiveness in a larger group (30-100 patients). Evaluates whether the treatment shows promise against the cancer.

21 trials

Phase 3

Compares new treatment to standard care (100-1000+ patients). Success here can lead to FDA approval.

2 trials

Treatment Categories

Immunotherapy

Treatments that help your immune system fight cancer, including checkpoint inhibitors like pembrolizumab and nivolumab.

34 trials

CAR-T Cell Therapy

Engineered immune cells designed to target mesothelin and other proteins on mesothelioma cells.

4 trials

Targeted Therapy

Drugs that target specific molecular pathways involved in mesothelioma growth.

6 trials

Chemotherapy

New chemotherapy combinations or delivery methods, often combined with immunotherapy.

15 trials

How to Enroll

  1. Talk to your oncologist: Discuss whether a clinical trial might be appropriate for your situation.
  2. Check eligibility: Each trial has specific criteria for who can participate.
  3. Contact the trial coordinator: Use the contact information on ClinicalTrials.gov.
  4. Understand the commitment: Trials may require additional visits, tests, and follow-up.