Pelvic Mesothelioma Tumor Shrinks 83% With Immunotherapy in Rare Case Report
Frontiers in Oncology case study shows toripalimab plus chemotherapy produced major tumor reduction in rare pelvic mesothelioma.
Frontiers in Oncology case study shows toripalimab plus chemotherapy produced major tumor reduction in rare pelvic mesothelioma.
Phase II PrE0505 trial shows durvalumab with pemetrexed-cisplatin yields 20.4-month median survival in unresectable pleural mesothelioma.
Phase III HIT-Meso trial compares proton beam therapy to surveillance across 25 UK centers, recruiting 148 people with pleural mesothelioma.
UH Cancer Center researchers discover a genetic mesothelioma variant caused by BAP1 mutations, not asbestos, that responds to standard treatment.
Five-year data from CheckMate-743 shows 14% survival with nivolumab plus ipilimumab vs 6% with chemotherapy. Non-epithelioid benefit is striking.
DREAM3R Phase 3 trial of durvalumab plus chemotherapy for pleural mesothelioma stopped early due to enrollment challenges. A 58% response rate, but no proof.
NEMO trial at Baylor and Duke is recruiting people with operable pleural mesothelioma to test chemoimmunotherapy before surgery.
Georgetown-Hopkins Phase 2 trial shows ctDNA blood test predicts which mesothelioma patients benefit from immunotherapy before surgery.
Mount Sinai reports zero perioperative mortality for pleurectomy/decortication in mesothelioma, challenging MARS2 trial skepticism.
Dr. Mohamed Adam's survival tree model uses mitotic rate, PCI, and histology to stage peritoneal mesothelioma and guide CRS-HIPEC decisions.
FDA-approved nivolumab plus ipilimumab improves mesothelioma survival. Learn how checkpoint inhibitors work, side effects, and who benefits.
Genetic testing for mesothelioma including BAP1, CDKN2A, and NGS panels. How results guide treatment decisions and clinical trial eligibility.
Rare mesothelioma cell types: desmoplastic, lymphohistiocytoid, deciduoid, and WDPM variants. Diagnosis challenges and prognosis.
Targeted therapy options for mesothelioma including BAP1, NF2, and TEAD inhibitors. Current clinical trials and who may benefit.
ATOMIC-Meso Phase 3 trial shows ADI-PEG20 plus chemotherapy improves survival in pleural mesothelioma. Analysis of this arginine-depleting therapy.
TEAD inhibitor IK-930 shows clinical activity in NF2-mutated mesothelioma at ESMO. First targeted therapy for this genetic subtype.
FDA grants Fast Track to UV1 telomerase vaccine for mesothelioma. Combined with immunotherapy, UV1 showed 64% response rate in trials.
PHASE3 clinical trial testing atezolizumab (Tecentriq) for mesothelioma. Trial NCT04996017 is recruiting.
Cancer Research UK PHASE1/PHASE2 clinical trial testing atezolizumab (Tecentriq) for people with mesothelioma. Trial NCT05944237 is now recruiting.
University Hospital, Antwerp PHASE1/PHASE2 clinical trial testing atezolizumab (Tecentriq) for people with mesothelioma. Trial NCT05765084 is now recruiting.
A2 Biotherapeutics Inc. N/A clinical trial testing CAR-T cell therapy for people with mesothelioma. Trial NCT04981119 is now recruiting.
A2 Biotherapeutics Inc. PHASE1/PHASE2 clinical trial testing CAR-T cell therapy for people with mesothelioma. Trial NCT06051695 is now recruiting.
UTC Therapeutics Inc. PHASE1 clinical trial testing CAR-T cell therapy for people with mesothelioma. Trial NCT06256055 is now recruiting.
National Cancer Institute (NCI) PHASE1 clinical trial testing CAR-T cell therapy for people with mesothelioma. Trial NCT06885697 is now recruiting.
Suzhou Maximum Bio-tech Co. Ltd. PHASE1 clinical trial testing CAR-T cell therapy for people with mesothelioma. Trial NCT06726564 is now recruiting.
Baylor College of Medicine PHASE1/PHASE2 clinical trial testing immunotherapy for people with mesothelioma. Trial NCT05932199 is now recruiting.
PHASE2 clinical trial testing HIPEC (heated intraperitoneal chemotherapy) for mesothelioma. Trial NCT05001880 is recruiting.
PHASE1 clinical trial testing HIPEC (heated intraperitoneal chemotherapy) for mesothelioma. Trial NCT04847063 is recruiting.
PHASE2 clinical trial testing HIPEC (heated intraperitoneal chemotherapy) for mesothelioma. Trial NCT06057935 is recruiting.
Udai Kammula PHASE2 clinical trial testing immunotherapy for mesothelioma patients. Trial NCT03935893 is now recruiting.
Brigham and Women's Hospital PHASE2 clinical trial testing immunotherapy for people with mesothelioma. Trial NCT05730816 is now recruiting.
Memorial Sloan Kettering Cancer Center PHASE2 clinical trial testing immunotherapy for people with mesothelioma. Trial NCT06477419 is now recruiting.
National Cancer Institute (NCI) PHASE2 clinical trial testing immunotherapy for people with mesothelioma. Trial NCT06503146 is now recruiting.
92 mesothelioma trials recruiting now. Immunotherapy leads with 32 trials, CAR-T emerges with 5. Complete 2026 data by state, phase, and treatment type.
Vivace Therapeutics, Inc PHASE1/PHASE2 clinical trial testing nivolumab plus ipilimumab for people with mesothelioma. Trial NCT04665206 is now recruiting.
Alliance phase 2 trial testing nivolumab + ipilimumab for mesothelioma. NCT05647265 is now recruiting patients.
7 Hills Pharma, LLC PHASE1/PHASE2 clinical trial testing nivolumab plus ipilimumab for people with mesothelioma. Trial NCT06362369 is now recruiting.
Istituto Oncologico Veneto IRCCS N/A clinical trial testing nivolumab plus ipilimumab for people with mesothelioma. Trial NCT06581549 is now recruiting.
AstraZeneca PHASE3 clinical trial testing nivolumab plus ipilimumab for people with mesothelioma. Trial NCT06097728 is now recruiting.
University Hospital, Antwerp PHASE1/PHASE2 clinical trial testing nivolumab plus ipilimumab for people with mesothelioma. Trial NCT07121374 is now recruiting.
University Hospital, Lille PHASE2 clinical trial testing nivolumab plus ipilimumab for people with mesothelioma. Trial NCT04400539 is now recruiting.
Memorial Sloan Kettering Cancer Center PHASE1 clinical trial testing pembrolizumab (Keytruda) for people with mesothelioma. Trial NCT04897022 is now recruiting.
Medicenna Therapeutics, Inc. PHASE1/PHASE2 clinical trial testing pembrolizumab (Keytruda) for people with mesothelioma. Trial NCT05086692 is now recruiting.
VM Oncology, LLC PHASE1/PHASE2 clinical trial testing pembrolizumab (Keytruda) for people with mesothelioma. Trial NCT03556228 is now recruiting.
Genmab PHASE1/PHASE2 clinical trial testing pembrolizumab (Keytruda) for people with mesothelioma. Trial NCT05579366 is now recruiting.
Tango Therapeutics, Inc. PHASE1/PHASE2 clinical trial testing pembrolizumab (Keytruda) for people with mesothelioma. Trial NCT05732831 is now recruiting.
KaliVir Immunotherapeutics PHASE1 clinical trial testing pembrolizumab (Keytruda) for people with mesothelioma. Trial NCT06444815 is now recruiting.
Hyogo Medical University PHASE2 clinical trial testing pembrolizumab (Keytruda) for people with mesothelioma. Trial NCT06318286 is now recruiting.
Johns Hopkins trial shows pre/post-surgery nivolumab + ipilimumab safe for operable mesothelioma, with 28.6-month median survival.
New Oncogene review maps BAP1 loss mechanisms in mesothelioma. 65% of cases involve BAP1 inactivation; EZH2 inhibitors emerge as potential targeted therapy.
A new cell therapy achieved tumor shrinkage in 63% of advanced mesothelioma patients. More than double typical response rates.
French biotech Oncovita receives FDA orphan drug designation for MVdeltaC, a modified measles virus showing 60-70% tumor reduction in mesothelioma models.
2025 saw major mesothelioma treatment advances including TEAD inhibitors, bispecific antibodies, and perioperative immunotherapy. Here's the full review.
A Dutch trial found two drugs achieved a 60% response rate in mesothelioma patients whose cancer returned after immunotherapy.
Novartis halted one experimental mesothelioma drug, but a competitor's TEAD inhibitor shows strong results in clinical trials.
An Australian trial will test Cyncado's TT-4 A2B receptor antagonist in ~50 people with mesothelioma after first-line therapy.
Honest answers to common questions about mesothelioma diagnosis, prognosis, treatment options, legal rights, and caregiving. Based on real patient concerns.
Drywall workers face mesothelioma risk from asbestos in joint compound used until 1977. Studies found 59% of workers had lung changes from exposure.
Diagnosed with peritoneal mesothelioma at 21 while pregnant, Tamron Little shares her 18-year journey and the reality of long-term survivorship.
Dr. Michele Carbone's team identified L-BAM. A genetic form of mesothelioma with dramatically better outcomes than asbestos-related disease.
Steel mill workers face elevated mesothelioma risk from asbestos used to protect against extreme heat. Studies show 2-4x higher disease rates.
September 26 is Mesothelioma Awareness Day. Learn about the history of awareness efforts, current statistics, and how to get involved.
Johns Hopkins phase 2 trial shows pre- and post-surgery immunotherapy is safe and effective for operable mesothelioma, with 28.6-month median survival.
Power plant workers face elevated mesothelioma rates from asbestos in boilers, turbines, and piping. Studies show 3-8x higher disease rates.
Patients on VT3989 went 40 weeks without cancer progression. Vs. 15 weeks on standard chemo. FDA granted Fast Track status.
A Johns Hopkins trial found that immunotherapy before and after surgery extended median survival to 28.6 months, 10 months longer than average.
Baylor and Duke are testing immunotherapy before surgery for mesothelioma. Trial now enrolling operable patients.
The IMPALA trial in France is testing intrapleural photodynamic therapy combined with nivolumab for inoperable mesothelioma. Results expected mid-2026.
Textile mill workers who manufactured asbestos cloth, rope, and fireproof fabrics face extremely high mesothelioma rates. Learn about exposure sources.
Oil refinery workers face elevated mesothelioma risk from asbestos insulation throughout refineries. Studies show 2-5x higher disease rates.
Railroad workers face elevated mesothelioma risk from asbestos in locomotives, brake systems, and rail facilities. FELA provides unique legal options.
Paul Kraus defied expectations for 27 years, becoming the world's longest-living mesothelioma survivor and patient advocate.
Teachers and school staff face asbestos exposure from deteriorating building materials. EPA data shows 45,000+ schools contain asbestos.
HVAC workers face mesothelioma risk from asbestos in duct insulation, boilers, and old equipment. Learn about exposure sources and protection.
BioNTech's dual-target immunotherapy achieved a 52% response rate in people with mesothelioma. Results presented at ASCO 2025.
While asbestos causes most mesothelioma, genetic factors like BAP1 mutations and Lynch syndrome can increase risk. Learn what genetics reveal.
Auto mechanics face mesothelioma risk from asbestos in brake pads and clutches. Learn about exposure history, current risks, and protection.
Proper nutrition supports mesothelioma treatment outcomes. Learn about caloric needs, protein requirements, and managing treatment side effects.
Mesothelioma is rare and often misdiagnosed. Learn why getting a second opinion is crucial and how to find specialized mesothelioma experts.
Dr. Harvey Pass has led the search for mesothelioma biomarkers. Blood tests that could detect the disease when treatment is most effective.
Mesothelioma staging determines treatment options and prognosis. Learn about the TNM system, survival rates by stage, and what staging means for you.
Mesothelioma requires specialized care. Learn what makes a treatment center qualified and how to find the right team for your diagnosis.
Caregiving for a mesothelioma patient is demanding. Learn practical tips for managing symptoms, appointments, emotions, and your own well-being.
FDA approval of Opdivo Qvantig allows subcutaneous nivolumab delivery in under 5 minutes, compared to 30-minute IV infusions for people with mesothelioma.
Australia's Wittenoom mining town became the nation's deadliest industrial disaster. More than 2,000 people have died from asbestos exposure.
Actor Paul Gleason, best known as Principal Vernon in The Breakfast Club, died of pleural mesothelioma in 2006, three weeks after diagnosis.
KEYNOTE-483 Phase 3 trial shows pembrolizumab plus chemotherapy improves survival to 17.3 months. FDA approved September 2024 for first-line treatment.
Multimodal therapy doubles mesothelioma survival rates. Trimodal protocols, HIPEC for peritoneal, and patient selection criteria explained.
Leonard Bernstein, creator of West Side Story and conductor of the New York Philharmonic, battled lung disease including a pleural tumor in his final years.
Dr. David Sugarbaker's contributions to mesothelioma surgery and training continue to shape how the disease is treated worldwide.
The Phase 2/3 DENIM trial found that dendritic cell vaccination did not extend overall survival for people with mesothelioma after chemotherapy.
Hall of Fame defensive tackle Merlin Olsen, 14-time Pro Bowler and actor, died of mesothelioma in 2010 after asbestos exposure from childhood construction work.
The landmark MARS 2 trial found that chemotherapy alone led to better survival than surgery plus chemotherapy for pleural people with mesothelioma.
The ATOMIC-Meso trial showed pegargiminase plus chemotherapy quadrupled 3-year survival rates in nonepithelioid mesothelioma, the most aggressive subtype.
The CONFIRM trial showed nivolumab extends survival 40% in relapsed mesothelioma. Biomarker analysis reveals who benefits most.
Warren Zevon's final months remain a powerful example of facing mortality with honesty and creativity after his mesothelioma diagnosis.
FDA grants fast-track to SynKIR-110 CAR-T therapy for mesothelioma. Phase 1 trial recruiting at MD Anderson, Penn, and more.
CAR-T cells target mesothelin on mesothelioma cells. SynKIR-110 received FDA fast-track in 2023. Multiple trials recruiting.
In October 2020, the FDA approved nivolumab plus ipilimumab as the first immunotherapy for mesothelioma, marking the first new treatment in 16 years.
Nivolumab plus ipilimumab improves survival to 18 months. See FDA-approved immunotherapies and current clinical trials.
CheckMate-743 trial shows nivolumab plus ipilimumab extends median survival to 18.1 months vs 14.1 months with chemotherapy. 3-year survival doubles.
Checkpoint inhibitors like nivolumab and pembrolizumab release the brakes on the immune system. Learn how PD-1 and CTLA-4 blockers treat mesothelioma.
When first-line chemo fails, second-line options include gemcitabine, immunotherapy combinations, and clinical trials. PEMMELA trial showed 60% response.
Guide to finding mesothelioma clinical trials on ClinicalTrials.gov. Active studies include CAR-T therapy, immunotherapy combinations, and targeted drugs.
In May 2019, the FDA approved the NovoTTF-100L System (Optune Lua) for mesothelioma, the first new treatment option since pemetrexed in 2004.
Tumor Treating Fields (Optune Lua) is FDA-approved for mesothelioma. Uses electric fields to disrupt cancer cell division with minimal side effects.
Women with mesothelioma have 3x better 5-year survival than men. 91% of female cases are from secondary household asbestos exposure.
Pemetrexed plus cisplatin extends median survival to 12.1 months. Response rates vary by cell type: epithelioid 16.5 months vs sarcomatoid 8.8 months.
22.6% of people with mesothelioma are initially misdiagnosed. Learn common conditions it's confused with and why second opinions matter.
CRS/HIPEC achieves 53-103 month median survival for peritoneal mesothelioma. 28-year data shows 43.6% cure rate for 7+ year survivors.
Pericardial mesothelioma affects the heart lining and accounts for less than 1% of cases. Learn about symptoms, diagnosis challenges, and treatment options.
Testicular mesothelioma affects less than 1% of patients but has the best prognosis. 49% five-year survival, symptoms, treatment, and outlook.
MESOMARK blood test detects elevated SMRP levels in mesothelioma. Learn about biomarkers for monitoring and early detection research.
Radiation therapy can control tumor growth and relieve symptoms for people with mesothelioma. Learn about IMRT, when radiation is used, and what to expect.
Palliative care improves quality of life for people with mesothelioma. Learn about symptom management, hospice eligibility, and support options.
Cell type determines mesothelioma prognosis. Epithelioid has best outcomes (~70% of cases). Learn how histology affects treatment response.
Surgery can extend survival for eligible people with mesothelioma. Compare pleurectomy/decortication and extrapleural pneumonectomy options.
65% of mesothelioma cases are diagnosed at Stage 3 or 4. Learn how staging works, survival rates by stage, and why early detection triples survival time.
Mesothelioma prognosis depends on stage, cell type, and treatment. Learn what factors influence survival and how to improve your outlook.
Complete guide to mesothelioma treatment options. Multimodal treatment achieves 32-month median survival. Learn about surgery, chemo, and immunotherapy.
Mesothelioma symptoms often mimic common conditions. Learn the warning signs of pleural, peritoneal, and other types. Early detection improves survival.
Peritoneal mesothelioma affects the abdominal lining. With HIPEC surgery, 5-year survival reaches 47-52%. Learn symptoms, treatment, and prognosis.
Pleural mesothelioma accounts for 80% of all cases. Learn about symptoms, staging, treatment options, and survival rates. 73% survive 1 year with treatment.
Asbestos exposure is the only proven cause of mesothelioma. Learn how asbestos fibers cause cancer, who is at risk, and the 20-50 year latency period.
Mesothelioma is a rare cancer caused by asbestos. Learn about types, symptoms, causes, and survival rates from independent medical sources.
BAP1 gene mutation increases mesothelioma risk after minimal asbestos exposure. Carriers average 7-year survival vs 12-21 months typical.